Prevacid contain Lansoprazole is a proton-pump inhibitor (PPI) which inhibits the stomach's production of gastric acids. In the United States it was first approved by the Food and Drug Administration (FDA) in 1995.

Uses :

Lansoprazole is indicated for :

• Treatment of ulcers of the stomach and duodenum, and NSAID-induced ulcers.
• Adjunctive treatment of Helicobacter pylori infection, alongside antibiotics. Treatment to kill Helicobacter pylori (H. pylori) causing ulcers or other problems involves using two other drugs besides lansoprazole. This treatment is known as "triple therapy", and involves taking twice daily for 10 or 14 days lansoprazole 30 mg, amoxicillin 1,000 mg, and clarithromycin 500 mg.
• Treatment of gastroesophageal reflux disease (GERD) also known as acid reflux disease.
• Treatment of Zollinger-Ellison Syndrome.

Drug interaction :

It interacts with some other drugs, either due to its own nature or as a proton pump inhibitor.

PPIs decrease absorption of anti fungals (itraconazole and ketoconazole) and maybe increase Digoxin in plasma

• Increases plasma concentrations of Cilostazol (risk of toxicity)
• Lansoprazole probably interacts with, amongst other drugs:
• sucralfate
• ampicillin
• bisacodyl
• clopidogrel
• delavirdine
• fluvoxamine
• iron salts
• voriconazole
• aminophylline and theophylline
• astemizole

Precautions :

Before you take this drug, tell your doctors if you :

• if you have low magnesium levels in your blood.
• have liver problems
• have phenyl ketonuria.
• have any other medical conditions
• are pregnant or plan to become pregnant. It is not known if PREVACID will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if this medicine passes into your breast milk. You and your doctor should decide if you will take PREVACID or breastfeed. You should not do both. Talk to your doctor about the best way to feed your baby if you taking this product.

Side effects :

Side effects of proton pump inhibitors include :

• Infrequent : dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus
• Rarely and very rarely : taste disturbance, liver dysfunction, peripheral oedema, hypersensitivity reactions (including bronchospasm, urinary, angioedema, anaphylaxis), photosensitivity,fever, sweating, depression, interstitial nephritis, blood disorders (including leukopenia, leukocytosis, pancytopenia, thrombocytopenia), arthralgia, myalgia, skin reactions including (erythroderma Stevens–Johnson syndrome, toxic epidermal necrolysis, bullous eruption)
• Severe : Gastro-intestinal disturbances (such as nausea 1.3%, abdominal pain 2.1%, diarrhea 3.8%).

Proton-pump inhibitors may be related with a greater risk of hip fractures and Clostridium difficile-associated diarrhea. Antacid product such as lansoprazole by suppressing acid mediated break down of proteins, leads to an elevated risk of developing food and drug allergies. This happens due to undigested proteins then passing into the gastrointestinal tract where sensitisation occurs. It is unclear whether this risk occurs with only long-term use or with short-term use as well. Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.

Storage :

Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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